4-Chloro-isatoic anhydride
4-Chloro-isatoic anhydride
CAS: 40928-13-0
Molecular Formula: C8H4ClNO3
4-Chloro-isatoic anhydride - Names and Identifiers
4-Chloro-isatoic anhydride - Physico-chemical Properties
| Molecular Formula | C8H4ClNO3 |
| Molar Mass | 197.58 |
| Density | 1.540±0.06 g/cm3(Predicted) |
| Melting Point | 255-259 °C |
| Solubility | soluble in Dimethylformamide |
| Appearance | powder to crystal |
| Color | White to Light yellow |
| pKa | 9.95±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.6 |
| MDL | MFCD00090431 |
4-Chloro-isatoic anhydride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
4-Chloro-isatoic anhydride - Introduction
4-Chloro-isatoic anhydride is an organic compound with the chemical formula C8H3ClO3. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 4-Chloro-isatoic anhydride are colorless or yellowish crystals.
-Melting point: approximately 210-212 degrees Celsius.
-Solubility: It has good solubility in most organic solvents.
Use:
- 4-Chloro-isatoic anhydride is commonly used in the synthesis of organic compounds, in organic synthesis as active reagents and catalyst raw materials.
-It can be used for the synthesis of isatin and other organic dyes, as well as the synthesis of certain drugs.
Preparation Method:
The preparation method of 4-Chloro-isatoic anhydride includes the following steps:
-First, 2-Nitro-isatoic acid (2-Nitro-isatoic acid) was synthesized by nitration reaction.
-Then, 2-nitroisatin acid is reacted with an acidic chlorinating agent under acidic conditions to obtain 4-chloroisatin acid.
-Finally, 4-chloroisatin acid is converted into 4-Chloroo-isatoic anhydride through a dehydration reaction.
Safety Information:
- 4-Chloro-isatoic anhydride may be irritating to the skin, eyes and respiratory system. Use should take appropriate protective measures, such as wearing gloves, goggles and protective masks.
-When used in the laboratory, safe operating procedures should be followed to avoid direct contact with the compound.
Nature:
-Appearance: 4-Chloro-isatoic anhydride are colorless or yellowish crystals.
-Melting point: approximately 210-212 degrees Celsius.
-Solubility: It has good solubility in most organic solvents.
Use:
- 4-Chloro-isatoic anhydride is commonly used in the synthesis of organic compounds, in organic synthesis as active reagents and catalyst raw materials.
-It can be used for the synthesis of isatin and other organic dyes, as well as the synthesis of certain drugs.
Preparation Method:
The preparation method of 4-Chloro-isatoic anhydride includes the following steps:
-First, 2-Nitro-isatoic acid (2-Nitro-isatoic acid) was synthesized by nitration reaction.
-Then, 2-nitroisatin acid is reacted with an acidic chlorinating agent under acidic conditions to obtain 4-chloroisatin acid.
-Finally, 4-chloroisatin acid is converted into 4-Chloroo-isatoic anhydride through a dehydration reaction.
Safety Information:
- 4-Chloro-isatoic anhydride may be irritating to the skin, eyes and respiratory system. Use should take appropriate protective measures, such as wearing gloves, goggles and protective masks.
-When used in the laboratory, safe operating procedures should be followed to avoid direct contact with the compound.
Last Update：2024-04-09 21:01:54
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